Periaxin, a PDZ domain protein expressed preferentially in myelinating Schwann cells
نویسندگان
چکیده
1. Department of Ophthalmology, Duke University School of Medicine, Durham. NC.USA 4 2. Department of Mechanical Engineering and Materials Science, Pratt School of 5 Engineering, Duke University. Durham. NC.USA 6 3. Centre for Neuroregeneration, University of Edinburgh, Edinburgh EH16 4SB, United 7 Kingdom 8 4. Howard Hughes Medical Institute, Chevy Chase, MD 20815; Department of 9 Biochemistry, Duke University School of Medicine, Durham. NC. USA 10 5. Department of Pharmacology and Cancer Biology, Duke University School of Medicine, 11 Durham. NC. USA 12
منابع مشابه
Nuclear Export of L-Periaxin, Mediated by Its Nuclear Export Signal in the PDZ Domain
Myelinating Schwann cells specifically express L-periaxin (L-PRX) in the mammalian peripheral nervous system. Several loss-of-function mutations in periaxin have been described and linked to autosomal recessive Dejerine Sottas neuropathy and to demyelinating Charcot-Marie-Tooth disease. The localization of L-periaxin is developmentally regulated in the nucleus and the plasma membrane of Schwann...
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Periaxin is a newly described protein that is expressed exclusively by myelinating Schwann cells. In developing nerves, periaxin is first detected as Schwann cells ensheathe axons, prior to the appearance of the proteins that characterize the myelin sheath. Periaxin is initially concentrated in the adaxonal membrane (apposing the axon) but, during development, as myelin sheaths mature, periaxin...
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Periaxin (Prx), a PDZ domain protein expressed preferentially in myelinating Schwann cells and lens fibers, plays a key role in membrane scaffolding and cytoarchitecture. Little is known, however, about how Prx is anchored to the plasma membrane. Here we report that ankyrin-B (AnkB), a well-characterized adaptor protein involved in linking the spectrin-actin cytoskeleton to integral membrane pr...
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The apposed membranes of myelinating Schwann cells are joined by several types of junctional specializations known as autotypic or reflexive junctions. These include tight, gap, and adherens junctions, all of which are found in regions of noncompact myelin: the paranodal loops, incisures of Schmidt-Lanterman, and mesaxons. The molecular components of autotypic tight junctions have not been esta...
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Dystroglycan-dystrophin complexes are believed to have structural and signaling functions by linking extracellular matrix proteins to the cytoskeleton and cortical signaling molecules. Here we characterize a dystroglycan-dystrophin-related protein 2 (DRP2) complex at the surface of myelin-forming Schwann cells. The complex is clustered by the interaction of DRP2 with L-periaxin, a homodimeric P...
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تاریخ انتشار 2015